Intro -- Preface -- Contents -- List of Contributors -- Human Brown Adipose Tissue Plasticity: Hormonal and Environmental Manipulation -- Introduction -- BAT and the Adaptive Thermogenesis Response -- Implications of the Rediscovery of BAT in Adult Humans -- Integrative Physiology Studies of Human Adaptive Thermogenesis -- Intervention Studies Aimed to Modulate the Human Adaptive Thermogenesis Response -- Manipulation of the Human Adaptive Thermogenesis Response by Hormones and Myokines -- Conclusions -- References -- The Energy Sensor AMPK: Adaptations to Exercise, Nutritional and Hormonal Signals -- Introduction -- AMPK: Structure and Regulation -- AMPK: Regulation by Hormones and Nutrients -- AMPK: Regulation by Exercise -- Control of Exercise-Induced Glucose Transport -- Control of Training-Induced Muscle Adaptations -- Control of Muscle Insulin Sensitivity -- Conclusions and Therapeutic Perspectives -- References -- Plasma Steroids and Cardiorespiratory Fitness Response to Regular Exercise -- Introduction -- Methods -- Subjects -- Anthropometric and Body Composition Measurements -- Aerobic Exercise Training Program -- VO2max Measurement -- Plasma Steroid Hormone and SHBG Concentrations -- Statistical Analysis -- Results -- Discussion -- References -- Sending the Signal: Muscle Glycogen Availability as a Regulator of Training Adaptation -- Introduction -- Fuels for the Fire: Patterns of Skeletal Muscle Fuel Utilization -- Sending the Signal: The Training Response-Adaptation -- Train-Low, Compete High: A Novel Strategy to Augment Training Adaptation -- Evolution of a Paradigm: Train-High, Sleep-Low -- Summary and Directions for Future Research -- References -- Optimized Engagement of Macrophages and Satellite Cells in the Repair and Regeneration of Exercised Muscle -- Introduction -- Repair and Regeneration After Muscle Damage.

Effects of Exercise and PGC-1(Sa(B on SCs -- Effects of Exercise and PGC-1(Sa(B on Macrophages and Inflammation -- Exercise-Induced Pre-conditioning for Faster Muscle Regeneration -- Conclusion -- References -- Skeletal Muscle microRNAs: Roles in Differentiation, Disease and Exercise -- Discovery and Biological Role of miRNAs -- miRNA Biogenesis, mRNA Interaction and Target Prediction -- Role of miRNAs in the Regulation of Skeletal Muscle Development -- Skeletal Muscle Development and Regeneration -- miRNA Regulation of Myogenesis In vitro and In vivo -- Skeletal Muscle miRNA in Metabolic Disease -- Skeletal Muscle miRNAs in Response to Exercise -- miRNA Regulation of Skeletal Muscle Atrophy and During States of Muscle Mass Loss -- Conclusions -- References -- Tryptophan-Kynurenine Metabolites in Exercise and Mental Health -- Introduction -- The PGC-1(Sa(B Family of Transcriptional Coactivators in Skeletal Muscle -- The Kyn Pathway of Tryptophan Degradation -- KP Metabolites and Mental Health -- Crosstalk Between Physical Exercise and KP Metabolites -- Future Perspectives and Considerations -- References -- The Role of FNDC5/Irisin in the Nervous System and as a Mediator for Beneficial Effects of Exercise on the Brain -- Introduction -- Discovery of FNDC5/Irisin -- Irisin in Humans -- FNDC5/Irisin in Exercise -- FNDC5/Irisin in Neuronal Development -- FNDC5/Irisin: Other Effects in the CNS -- Exercise Induces Hippocampal BDNF Through a PGC-1(Sa(B/FNDC5 Pathway -- Other Circulating Factors from the Muscle -- References.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2022. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.